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Article

Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.

DNA repair - 1 Jul 2016

Moiseeva Tatiana N, Gamper Armin M, Hood Brian L, Conrads Thomas P, Bakkenist Christopher J

Abstract excerpt

We describe a dynamic phosphorylation on serine-1940 of the catalytic subunit of human Pol ε, POLE1, following DNA damage. We also describe novel interactions between POLE1 and the iron-sulfur cluster assembly complex CIA proteins CIAO1 and MMS19. We show that serine-1940 is essential for the interaction between POLE1 and MMS19, but not POLE1 and CIAO1. No defect in either proliferation or survival was identified...

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Source

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Identifiers

PMID: 27235625
DOI: 10.1016/j.dnarep.2016.04.007
PMCID: PMC4917431

Genes

MMS19
CIAO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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