Article

The iron-sulfur cluster is critical for DNA binding by human DNA polymerase ε

2022-05-05

Abstract excerpt

<h4>ABSTRACT</h4> DNA polymerase ε (Polε) is a key enzyme for DNA replication in eukaryotes. It is attached to a helicase and performs DNA synthesis on the leading strand. Recently it was shown that the catalytic domain of yeast Polε (Polε CD ) contains a [4Fe-4S] cluster located at the base of the processivity domain (P-domain) and coordinated by four conserved cysteines. In this work, we have shown that human...

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Literature Corpus work: c08ae8bd-af66-593b-84c6-35394ac93155
DOI: 10.1101/2022.05.05.490830

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