Article

Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control

2025-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Hsp70s are essential molecular chaperones that are increasingly recognized to be regulated by post-translational modifications. Here, we show that phosphorylation of a conserved threonine (T495), previously shown to be exploited by a Legionella pneumophila kinase to inhibit Hsp70, occurs endogenously in human cells in response to DNA damage, particularly when base excision repair is overburdene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a9560e1-9de9-5f23-8eaf-0de8d361246e
DOI: 10.1101/2025.09.05.672953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle controlDOI 10.1101/2025.09.05.672953Read

The phosphoproteomic landscape of the DNA damage responseSemantic proximity Read

DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase functionSemantic proximity Read

Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein EngineeringSemantic proximity Read

Growth-regulated Hsp70 phosphorylation regulates stress responses and prion maintenanceSemantic proximity Read

Histone Phosphorylation in DNA Damage ResponseSemantic proximity Read

Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation.Semantic proximity Read

Histone Phosphorylation in DNA Damage ResponseSemantic proximity Read

The Role of Non-Canonical Hsp70s (Hsp110/Grp170) in CancerSemantic proximity Read

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.Semantic proximity Read

Phosphorylation Control of p53 DNA-Binding Cooperativity Balances Tumorigenesis and AgingSemantic proximity Read

A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.Semantic proximity Read

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.Semantic proximity Read