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SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

13 Mar 2012

Abstract excerpt

Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1), which removes stalled topoisomerase 1 peptides from DNA termini. Here we show that TDP1 is a substrate for...

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PMID: 22415824
DOI: 10.1038/ncomms1739

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