Article

Inactivation of a protein hydroxylase complex impairs replication fork restart in cancer and neurodevelopmental disorders

2025-11-25

Abstract excerpt

Protein hydroxylation is a post-translational modification that is commonly catalysed by enzymes of the oxygen- and 2-oxoglutarate (2OG)-dependent oxygenase family. The Jumonji-C (JmjC)-only sub-family of 2OG-oxygenases catalyse the hydroxylation of protein and tRNA substrates involved in fundamental cellular processes. Jumonji-domain 5 (JMJD5) is a highly conserved and essential 2OG-oxygenase that, thus far, is t...

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Literature Corpus work: 40a5a520-2037-5726-8810-b64fdfa00d70
DOI: 10.1101/2025.11.22.689938

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