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Regulation and Modulation of Human DNA Polymerase δ Activity and Function

24 Jul 2017

Abstract excerpt

This review focuses on the regulation and modulation of human DNA polymerase δ (Pol δ). The emphasis is on the mechanisms that regulate the activity and properties of Pol δ in DNA repair and replication. The areas covered are the degradation of the p12 subunit of Pol δ, which converts it from a heterotetramer (Pol δ4) to a heterotrimer (Pol δ3), in response to DNA damage and also during the cell cycle. The...

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PMID: 28737709
DOI: 10.3390/genes8070190

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