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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

15 Feb 2021

Abstract excerpt

Upon binding to DNA breaks, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other factors to initiate DNA repair. Serine is the major residue for ADP-ribosylation upon DNA damage, which strictly depends on HPF1. Here, we report the crystal structures of human HPF1/PARP1-CAT ΔHD complex at 1.98 Å resolution, and mouse and human HPF1 at 1.71 Å and 1.57 Å resolution, respectively. Our structures and...

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PMID: 33589610
DOI: 10.1038/s41467-021-21302-4

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