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Article

Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC).

Carcinogenesis - 1 Aug 2016

Xicola Rosa M, Bontu Sneha, Doyle Brian J, Rawson Jamie, Garre Pilar, Lee Esther, de la Hoya Miguel, Bessa Xavier, Clofent Joan, Bujanda Luis, Balaguer Francesc, Castellví-Bel Sergi, Alenda Cristina, Jover Rodrigo, Ruiz-Ponte Clara, Syngal Sapna, Andreu Montserrat, Carracedo Angel, Castells Antoni, Newcomb Polly A, Lindor Noralane, Potter John D, Baron John A, Ellis Nathan A, Caldes Trinidad, LLor Xavier

Abstract excerpt

The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85...

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Source

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Identifiers

PMID: 27234654
DOI: 10.1093/carcin/bgw064
PMCID: PMC4967215

Genes

TGFBR1
AXIN2
CTNNB1
MGMT
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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