Article
Genetic variants in the TGFβ-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.
Oncotarget - 7 Mar 2017
Slattery Martha L, Trivellas Andromahi, Pellatt Andrew J, Mullany Lila E, Stevens John R, Wolff Roger K, Herrick Jennifer S
Abstract excerpt
The TGF-β signaling pathway is involved in regulation of cell growth, angiogenesis, and metastasis. We test the hypothesis that genetic variation in the TGF-β signaling pathway alters miRNA expression.We use data from 1188 colorectal cancer cases to evaluate associations between 80 SNPs in 21 genes.Seven variants eIF4E rs12498533, NFκB1 rs230510, TGFB1 rs4803455, TGFBR1 rs1571590 and rs6478974, SMAD3 ,...