Article
A low-frequency variant in SMAD7 modulates TGF-β signaling and confers risk for colorectal cancer in Chinese population.
Molecular carcinogenesis - 1 Jul 2017
Li Jiaoyuan, Zou Li, Zhou Ying, Li Lu, Zhu Ying, Yang Yang, Gong Yajie, Lou Jiao, Ke Juntao, Zhang Yi, Tian Jianbo, Zou Danyi, Peng Xiating, Chang Jiang, Gong Jing, Zhong Rong, Zhou Xiaobo, Miao Xiaoping
Abstract excerpt
The TGF-β pathway plays an essential role in regulating cell proliferation and differentiation. GWASs and candidate approaches have identified a battery of genetic variants in the TGF-β pathway contributing to colorectal cancer (CRC). However, most of the significant variants are common variants and their functions remain ambiguous. To identify causal variants with low-frequency in the TGF-β pathway contributing...
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