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Article

Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2011

Slattery Martha L, Herrick Jennifer S, Lundgreen Abbie, Wolff Roger K

Abstract excerpt

BACKGROUND: The TGF-β signaling pathway is an essential regulator of many cellular process involved in carcinogenesis. Smad proteins are central to the function of TGF-β signaling. In this study, we evaluated genetic variation in TGFβ1, TGFβR1, Smad1, Smad2, Smad3, and Smad4 and risk of colon and rectal cancer. METHODS: Data are from a large case-control study of colon (n = 1,444 cases, 1,841 controls) and rectal...

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PMID: 21068203
DOI: 10.1158/1055-9965.EPI-10-0843
PMCID: PMC3061458

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