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Article

CRISPR-directed mitotic recombination enables genetic mapping without crosses.

Science (New York, N.Y.) - 27 May 2016

Sadhu Meru J, Bloom Joshua S, Day Laura, Kruglyak Leonid

Abstract excerpt

Linkage and association studies have mapped thousands of genomic regions that contribute to phenotypic variation, but narrowing these regions to the underlying causal genes and variants has proven much more challenging. Resolution of genetic mapping is limited by the recombination rate. We developed a method that uses CRISPR (clustered, regularly interspaced, short palindromic repeats) to build mapping panels...

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Identifiers

PMID: 27230379
DOI: 10.1126/science.aaf5124
PMCID: PMC4933295

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Source receipt: pubmed, retrieved 7 Sept 2026.

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