Article
Non-uniform chromosomal SNP density biases sites of meiotic crossovers in Drosophila melanogaster.
G3 (Bethesda, Md.) - 3 Jun 2026
Hinson Savanna, Sangston Ryan, Cichewicz Karol, Konduru Guruprasad, Parikh Ishan, Hirsh Jay
Abstract excerpt
Here we localize a genetic suppressor that enhances the reduced locomotor activity phenotype of flies lacking brain dopamine. We utilized a bulk segregant analysis mapping strategy coupled with whole genome sequencing, mapping the trait to a roughly 3.5 mega-base region of the X chromosome. However, this mapping yielded ∼5-fold lower resolution than anticipated, due to an uneven distribution of single nucleotide...
Topics
- Animals
- Polymorphism, Single Nucleotide
- Drosophila melanogaster
- Chromosome Mapping
- Crossing Over, Genetic
- Meiosis
- X Chromosome
- Chromosomes, Insect
- Recombination, Genetic
- Phenotype
- Female