Non-uniform chromosomal SNP density biases sites of meiotic crossovers in Drosophila melanogaster.

Abstract excerpt

Here we localize a genetic suppressor that enhances the reduced locomotor activity phenotype of flies lacking brain dopamine. We utilized a bulk segregant analysis mapping strategy coupled with whole genome sequencing, mapping the trait to a roughly 3.5 mega-base region of the X chromosome. However, this mapping yielded ∼5-fold lower resolution than anticipated, due to an uneven distribution of single nucleotide...

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