Article
Using Mass Spectrometry to Quantify Rituximab and Perform Individualized Immunoglobulin Phenotyping in ANCA-Associated Vasculitis.
Analytical chemistry - 21 Jun 2016
Mills John R, Cornec Divi, Dasari Surendra, Ladwig Paula M, Hummel Amber M, Cheu Melissa, Murray David L, Willrich Maria A, Snyder Melissa R, Hoffman Gary S, Kallenberg Cees G M, Langford Carol A, Merkel Peter A, Monach Paul A, Seo Philip, Spiera Robert F, St Clair E William, Stone John H, Specks Ulrich, Barnidge David R
Abstract excerpt
Therapeutic monoclonal immunoglobulins (mAbs) are used to treat patients with a wide range of disorders including autoimmune diseases. As pharmaceutical companies bring more fully humanized therapeutic mAb drugs to the healthcare market analytical platforms that perform therapeutic drug monitoring (TDM) without relying on mAb specific reagents will be needed. In this study we demonstrate that...
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