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Article

Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay.

mAbs - 1 Jan 2024

Dong Linlin, Chen Susan, Piatkov Konstantin, Wei Dong, Qian Mark G

Abstract excerpt

A sensitive and specific bioanalytical method was required to measure the exposure of a LAGA-mutated surrogate mouse IgG2a monoclonal antibody in mouse plasma, but the lack of highly specific reagents for the LAGA mutant hindered the development of a ligand-binding assay. Equally problematic is that no sensitive unique tryptic peptides suitable for quantitative mass spectrometric analysis could be identified in...

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Identifiers

PMID: 39077932
DOI: 10.1080/19420862.2024.2379903
PMCID: PMC11290748

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