Article

Multi Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific Conjugation

2022-08-16

Abstract excerpt

Antibody drug conjugates are a class of biotherapeutic proteins which have been extensively developed in recent years resulting in new approvals and improved standard of care for cancer patients. Among the numerous strategies of conjugating cytotoxic payloads to monoclonal antibodies, insertion of a cysteine residue at position 239 (C239i) achieves a tightly controlled, site specific drug to antibody ratio. Tailor...

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Literature Corpus work: 94407d23-768b-5047-8b87-4865648cab79
DOI: 10.22541/au.166062796.68296258/v1

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