Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry.

Journal of proteome research - 7 Nov 2014

Barnidge David R, Dasari Surendra, Ramirez-Alvarado Marina, Fontan Adrian, Willrich Maria A V, Tschumper Renee C, Jelinek Diane F, Snyder Melissa R, Dispenzieri Angela, Katzmann Jerry A, Murray David L

Abstract excerpt

We previously described a microLC-ESI-Q-TOF MS method for identifying monoclonal immunoglobulins in serum and then tracking them over time using their accurate molecular mass. Here we demonstrate how the same methodology can be used to identify and characterize polyclonal immunoglobulins in serum. We establish that two molecular mass distributions observed by microLC-ESI-Q-TOF MS are from polyclonal kappa and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinemia
Share to Hypergammaglobulinemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin G

Share to Immunoglobulin lambda-Chains

Share to Immunoglobulin Light Chains

Share to Linear Models

Share to Molecular Weight

Share to Spectrometry, Mass, Electrospray Ionization

Source

Identifiers

PMID: 25134970
DOI: 10.1021/pr5005967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry.PMID 25134970Read ↗

Subset of Kappa and Lambda Germline Sequences Result in Light Chains with a Higher Molecular Mass Phenotype.Semantic proximity Read ↗

Human plasma IgG1 repertoires are simple, unique, and dynamicSemantic proximity Read ↗

The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodiesSemantic proximity Read ↗

Human Plasma IgG1 Repertoires are Simple, Unique, and DynamicSemantic proximity Read ↗

Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoiresSemantic proximity Read ↗

An updated AL-base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis.Semantic proximity Read ↗

Using Mass Spectrometry to Quantify Rituximab and Perform Individualized Immunoglobulin Phenotyping in ANCA-Associated Vasculitis.Semantic proximity Read ↗

An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosisSemantic proximity Read ↗

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foeSemantic proximity Read ↗

Direct Comparison of the Hinge-Cleaving Proteases IgdE and BdpK for LC-MS-Based IgG1 Clonal ProfilingSemantic proximity Read ↗

Laboratory characterizations on 2007 cases of monoclonal gammopathies in East China.Semantic proximity Read ↗

Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.