Article
Subset of Kappa and Lambda Germline Sequences Result in Light Chains with a Higher Molecular Mass Phenotype.
Journal of proteome research - 4 Dec 2015
Barnidge David R, Lundström Susanna L, Zhang Bo, Dasari Surendra, Murray David L, Zubarev Roman A
Abstract excerpt
In our previous work, we showed that electrospray ionization of intact polyclonal kappa and lambda light chains isolated from normal serum generates two distinct, Gaussian-shaped, molecular mass distributions representing the light-chain repertoire. During the analysis of a large (>100) patient sample set, we noticed a low-intensity molecular mass distribution with a mean of approximately 24 250 Da, roughly 800...
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