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Article

Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies.

mAbs - 1 Jan 2000

Xie Hongwei, Chakraborty Asish, Ahn Joomi, Yu Ying Qing, Dakshinamoorthy Deepalakshmi P, Gilar Martin, Chen Weibin, Skilton St John, Mazzeo Jeffery R

Abstract excerpt

This study shows that state-of-the-art liquid chromatography (LC) and mass spectrometry (MS) can be used for rapid verification of identity and characterization of sequence variants and posttranslational modifications (PTMs) for antibody products. A candidate biosimilar IgG1 monoclonal antibody (mAb) was compared in detail to a commercially available innovator product. Intact protein mass, primary sequence, PTMs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20458189
DOI: 10.4161/mabs.11986
PMCID: PMC3180085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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