Article
Development and validation of a semi-automated hybrid immunocapture liquid chromatography-mass spectrometry method to quantify LALA-mutated biotherapeutics in mouse plasma.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Aug 2026
Papa Vittoria, De Salve Ilse, Molinaro Francesco, Ianni Andrea Di, Monge Stefania, Mastroianni Rita, Ariaudo Alessandra, Tavano Patrizia, Castagna Valeria, Cowan Kyra, Sirtori Federico Riccardi
Abstract excerpt
Biotherapeutic antibodies are increasingly being developed and, various strategies have recently been used to maximize their potential therapeutic efficacy. The crystallizable fragment (Fc) region of therapeutic monoclonal antibodies (mAbs) is often engineered to tailor their effector functions and pharmacokinetic (PK) properties by introducing point mutations. Notably, most of these mutations are in the hinge...
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