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Article

Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.

Science signaling - 24 May 2016

Matalon Omri, Fried Sophia, Ben-Shmuel Aviad, Pauker Maor H, Joseph Noah, Keizer Danielle, Piterburg Marina, Barda-Saad Mira

Abstract excerpt

Natural killer (NK) cells discriminate between healthy cells and virally infected or transformed self-cells by tuning activating and inhibitory signals received through cell surface receptors. Inhibitory receptors inhibit NK cell function by recruiting and activating the tyrosine phosphatase Src homology 2 (SH2) domain-containing protein tyrosine phosphatase-1 (SHP-1) to the plasma membrane. However, to date, the...

Read the complete abstract on PubMed

Topics

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Share to Fluorescence Resonance Energy Transfer
Share to Image Processing, Computer-Assisted

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Microscopy, Confocal

Share to Phospholipase C gamma

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Receptors, KIR2DL1

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Source

Identifiers

PMID: 27221712
DOI: 10.1126/scisignal.aad6182

Genes

LAT
VAV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.PMID 27221712Read ↗

Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.Semantic proximity Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.Semantic proximity Read ↗

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.Semantic proximity Read ↗

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells.Semantic proximity Read ↗

Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation.Semantic proximity Read ↗

The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.Semantic proximity Read ↗

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