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Article

Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.

Molecular and cellular biology - 1 Sept 2003

Stebbins Christopher C, Watzl Carsten, Billadeau Daniel D, Leibson Paul J, Burshtyn Deborah N, Long Eric O

Abstract excerpt

Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through inhibitory receptors. Interaction of activation receptors with their ligands on target cells induces cytotoxicity by NK cells. This activation is under negative control by inhibitory...

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Share to Binding, Competitive
Share to Cytotoxicity, Immunologic
Share to Cytotoxicity Tests, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Proto-Oncogene Proteins c-vav

Share to Receptors, Immunologic

Share to Receptors, KIR

Source

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Identifiers

PMID: 12917349
DOI: 10.1128/MCB.23.17.6291-6299.2003
PMCID: PMC180957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12917349-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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