Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

19 May 2016

Abstract excerpt

UNLABELLED: Interferons (IFNs) restrict various kinds of viral infection via induction of hundreds of IFN-stimulated genes (ISGs), while the functions of the majority of ISGs are broadly unclear. Here, we show that a high-IFN-inducible gene, ISG12a (also known as IFI27), exhibits a nonapoptotic antiviral effect on hepatitis C virus (HCV) infection. Viral NS5A protein is targeted specifically by ISG12a, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to interferon and immune responses
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27194766
DOI: 10.1128/jvi.00352-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation PathwayPMID 27194766Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune ResponseSemantic proximity Read ↗

The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.Semantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune ResponseSemantic proximity Read ↗

Interferon-Stimulated Genes: What Do They All Do?Semantic proximity Read ↗

Interferon Inducer IFI35 Regulates RIG-I-Mediated Innate Antiviral Response through Mutual Antagonism with Influenza Virus Protein NS1Semantic proximity Read ↗

Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathwaySemantic proximity Read ↗

IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradationSemantic proximity Read ↗

ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatmentSemantic proximity Read ↗

Recent advances in antiviral interferon-stimulated gene biologySemantic proximity Read ↗

TRIM22 suppresses zika virus replication by targeting NS1 and NS3 for proteasomal degradationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.