Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment

21 Oct 2009

Abstract excerpt

Upregulation of interferon (IFN)-stimulated genes (ISGs), including IFN-stimulated gene 15 (ISG15) and other members of the ISG15 pathway, in pre-treatment liver tissue of patients chronically infected with hepatitis C virus (HCV) is associated with subsequent treatment failure (pegylated IFN-alpha/ribavirin). This study assessed the effect of ISG15 on HCV production in vitro. The levels of ISG15 and of its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to interferon and immune responses
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19846672
DOI: 10.1099/vir.0.015388-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatmentPMID 19846672Read ↗

The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response.Semantic proximity Read ↗

ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus ReplicationSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus RegulatorsSemantic proximity Read ↗

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune ResponseSemantic proximity Read ↗

ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive systemSemantic proximity Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

Modulation of alpha interferon anti-hepatitis C virus activity by ISG15Semantic proximity Read ↗

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.