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Article

IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation

8 Sept 2015

Abstract excerpt

RNA virus infection is recognized by the RIG-I family of receptors that activate the mitochondrial adaptor MAVS, leading to the clearance of viruses. Antiviral signalling activation requires strict modulation to avoid damage to the host from exacerbated inflammation. Insulin receptor tyrosine kinase substrate (IRTKS) participates in actin bundling and insulin signalling and its deficiency causes insulin...

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PMID: 26348439
DOI: 10.1038/ncomms9132

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