Article
TRIM22 suppresses zika virus replication by targeting NS1 and NS3 for proteasomal degradation
2022-06-14
Abstract excerpt
<h4>Background: </h4> Recognition of viral invasion by innate antiviral immune system triggers activation of the Type I-interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression of a group of genes known as IFN-I-stimulated genes (ISGs) to block viral infection. The Tripartite Ring Interaction Motif 22 (TRIM22) is an ISG with strong antiviral functions. <h4>Resul...
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Identifiers and source
- Literature Corpus work
- 122f1c60-5286-50ac-9b30-5237fcbc3bee
- DOI
- 10.21203/rs.3.rs-1727828/v1