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Article

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response

13 Oct 2011

Abstract excerpt

Recognition of viral RNA structures by the intracytosolic RNA helicase RIG-I triggers induction of innate immunity. Efficient induction requires RIG-I ubiquitination by the E3 ligase TRIM25, its interaction with the mitochondria-bound MAVS protein, recruitment of TRAF3, IRF3- and NF-κB-kinases and transcription of Interferon (IFN). In addition, IRF3 alone induces some of the Interferon-Stimulated Genes (ISGs),...

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PMID: 22022264
DOI: 10.1371/journal.ppat.1002289

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