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Article

Power considerations for λ inflation factor in meta-analyses of genome-wide association studies.

Genetics research - 19 May 2016

Georgiopoulos Georgios, Evangelou Evangelos

Abstract excerpt

The genomic control (GC) approach is extensively used to effectively control false positive signals due to population stratification in genome-wide association studies (GWAS). However, GC affects the statistical power of GWAS. The loss of power depends on the magnitude of the inflation factor (λ) that is used for GC. We simulated meta-analyses of different GWAS. Minor allele frequency (MAF) ranged from 0·001 to...

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Identifiers

PMID: 27193946
DOI: 10.1017/S0016672316000069
PMCID: PMC6865175

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MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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