Article
Strategies for genetic model specification in the screening of genome-wide meta-analysis signals for further replication.
International journal of epidemiology - 1 Apr 2011
Pereira Tiago V, Patsopoulos Nikolaos A, Pereira Alexandre C, Krieger José E
Abstract excerpt
BACKGROUND: Meta-analysis is increasingly being employed as a screening procedure in large-scale association studies to select promising variants for follow-up studies. However, standard methods for meta-analysis require the assumption of an underlying genetic model, which is typically unknown a priori. This drawback can introduce model misspecifications, causing power to be suboptimal, or the evaluation of...
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