Article
Genomic inflation factors under polygenic inheritance.
European journal of human genetics : EJHG - 1 Jul 2011
Yang Jian, Weedon Michael N, Purcell Shaun, Lettre Guillaume, Estrada Karol, Willer Cristen J, Smith Albert V, Ingelsson Erik, O'Connell Jeffrey R, Mangino Massimo, Mägi Reedik, Madden Pamela A, Heath Andrew C, Nyholt Dale R, Martin Nicholas G, Montgomery Grant W, Frayling Timothy M, Hirschhorn Joel N, McCarthy Mark I, Goddard Michael E, Visscher Peter M
Abstract excerpt
Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean test statistic for association calculated from multiple single-nucleotide-polymorphisms across the genome is used to assess such effects, and 'genomic control' can be applied subsequently to adjust test statistics at...
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