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Article

Correcting for Genomic Inflation Leads to Loss of Power in Large-Scale Genome-Wide Association Study Meta-Analysis.

Genetic epidemiology - 1 Sept 2025

Singh Archit, Southam Lorraine, Hatzikotoulas Konstantinos, Rayner Nigel W, Suzuki Ken, Taylor Henry J, Yin Xianyong, Mandla Ravi, Huerta-Chagoya Alicia, Morris Andrew P, Zeggini Eleftheria, Bocher Ozvan

Abstract excerpt

Inflation in genome-wide association studies (GWAS) summary statistics represents a major challenge, for which correction methods have been developed. These include the genomic control (GC) method, which uses the λ-value to correct summary statistics, and the linkage disequilibrium score regression (LDSR) method, which uses the LDSR intercept. By using type 2 diabetes (T2D) as an exemplar, we explore factors...

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PMID: 40767503
DOI: 10.1002/gepi.70016
PMCID: PMC12327166

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GC

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