Article
Cohen's h for detection of disease association with rare genetic variants.
BMC genomics - 8 Oct 2014
Wen Shu-Hui, Yeh Jih-I
Abstract excerpt
BACKGROUND: The power of the genome wide association studies starts to go down when the minor allele frequency (MAF) is below 0.05. Here, we proposed the use of Cohen's h in detecting disease associated rare variants. The variance stabilizing effect based on the arcsine square root transformation of MAFs to generate Cohen's h contributed to the statistical power for rare variants analysis. We re-analyzed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.