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Article

Development and application of genomic control methods for genome-wide association studies using non-additive models.

PloS one - 1 Jan 2013

Tsepilov Yakov A, Ried Janina S, Strauch Konstantin, Grallert Harald, van Duijn Cornelia M, Axenovich Tatiana I, Aulchenko Yurii S

Abstract excerpt

Genome-wide association studies (GWAS) comprise a powerful tool for mapping genes of complex traits. However, an inflation of the test statistic can occur because of population substructure or cryptic relatedness, which could cause spurious associations. If information on a large number of genetic markers is available, adjusting the analysis results by using the method of genomic control (GC) is possible. GC was...

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Identifiers

PMID: 24358113
DOI: 10.1371/journal.pone.0081431
PMCID: PMC3864791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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