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Article

The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis.

PLoS genetics - 1 May 2016

Budirahardja Yemima, Tan Pei Yi, Doan Thang, Weisdepp Peter, Zaidel-Bar Ronen

Abstract excerpt

The evolutionarily conserved family of AP-2 transcription factors (TF) regulates proliferation, differentiation, and apoptosis. Mutations in human AP-2 TF have been linked with bronchio-occular-facial syndrome and Char Syndrome, congenital birth defects characterized by craniofacial deformities and patent ductus arteriosus, respectively. How mutations in AP-2 TF cause the disease phenotypes is not well...

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Identifiers

PMID: 27176626
DOI: 10.1371/journal.pgen.1006048
PMCID: PMC4866721

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Source receipt: pubmed, retrieved 7 Sept 2026.

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