Article
Drosophila transcription factor AP-2 in proboscis, leg and brain central complex development.
Development (Cambridge, England) - 1 Apr 2001
Monge I, Krishnamurthy R, Sims D, Hirth F, Spengler M, Kammermeier L, Reichert H, Mitchell P J
Abstract excerpt
We report loss- and gain-of-function analyses that identify essential roles in development for Drosophila transcription factor AP-2. A mutagenesis screen yielded 16 lethal point mutant alleles of dAP-2. Null mutants die as adults or late pupae with a reduced proboscis, severely shortened legs (approximately 30% of normal length) lacking tarsal joints, and disruptions in the protocerebral central complex, a brain...
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