Article
The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.
Developmental biology - 1 Jul 2004
Fay David S, Qiu Xiaohui, Large Edward, Smith Christopher P, Mango Susan, Johanson Bethany L
Abstract excerpt
Organ development is a complex process involving the coordination of cell proliferation, differentiation, and morphogenetic events. Using a screen to identify genes that function coordinately with lin-35/Rb during animal development, we have isolated a weak loss-of-function (LOF) mutation in pha-1. lin-35; pha-1 double mutants are defective at an early step in pharyngeal morphogenesis leading to an abnormal...
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