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Article

FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.

eLife - 23 Mar 2015

Kelley Melissa, Yochem John, Krieg Michael, Calixto Andrea, Heiman Maxwell G, Kuzmanov Aleksandra, Meli Vijaykumar, Chalfie Martin, Goodman Miriam B, Shaham Shai, Frand Alison, Fay David S

Abstract excerpt

During development, biomechanical forces contour the body and provide shape to internal organs. Using genetic and molecular approaches in combination with a FRET-based tension sensor, we characterized a pulling force exerted by the elongating pharynx (foregut) on the anterior epidermis during C. elegans embryogenesis. Resistance of the epidermis to this force and to actomyosin-based circumferential constricting...

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Biomechanical Phenomena
Epidermis
Fibrillins
Fluorescence Resonance Energy Transfer
Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stress, Mechanical

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PMID: 25798732
DOI: 10.7554/eLife.06565
PMCID: PMC4395870

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