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Article

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.

Clinical pharmacokinetics - 1 Jul 2015

Wolking Stefan, Schaeffeler Elke, Lerche Holger, Schwab Matthias, Nies Anne T

Abstract excerpt

ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1) is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma membrane of many different cell types. Numerous structurally unrelated compounds, including drugs and environmental toxins, have been identified as substrates. ABCB1 limits the absorption of xenobiotics from the gut lumen, protects...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Drug Transport and Resistance Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemoglobinopathies and Related Disorders

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 25860377
DOI: 10.1007/s40262-015-0267-1

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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