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Article

Influence of ABCB1 genetic variants in breast cancer treatment outcomes.

Cancer epidemiology - 1 Oct 2013

Chaturvedi P, Tulsyan S, Agarwal G, Lal P, Agarwal S, Mittal R D, Mittal B

Abstract excerpt

BACKGROUND: Transportation of anticancer drugs such as anthracyclines across the membrane is regulated by P-glycoprotein encoded by the human multidrug resistance gene 1 (ABCB1). Polymorphisms in the ABCB1 gene (1236C>T, 2677G>T/A, 3435C>T) have been found to be associated with intrinsic and acquired cross resistance to these anticancer drugs. Therefore, the aim of this study is to evaluate the influence of ABCB1...

Topics

ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Breast Neoplasms
Chemotherapy, Adjuvant
Drug Resistance, Neoplasm
Female
Genetic Variation
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Neoadjuvant Therapy

Polymorphism, Genetic

Source

Identifiers

PMID: 23707158
DOI: 10.1016/j.canep.2013.04.012

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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