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Article

Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

G3 (Bethesda, Md.) - 1 Jun 2016

Hoffman Kyle S, Duennwald Martin L, Karagiannis Jim, Genereaux Julie, McCarton Alexander S, Brandl Christopher J

Abstract excerpt

The TTT complex is composed of the three essential proteins Tel2, Tti1, and Tti2 The complex is required to maintain steady state levels of phosphatidylinositol 3-kinase-related kinase (PIKK) proteins, including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical cell signaling pathways. Due to their association with heat shock proteins, and with newly synthesized PIKK peptides,...

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Share to Cell Survival
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Share to HSP90 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Chaperones

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Share to Stress, Physiological

Source

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Identifiers

PMID: 27172216
DOI: 10.1534/g3.116.029520
PMCID: PMC4889661

Genes

ATM
ATR
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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