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Article

Tel2 regulates the stability of PI3K-related protein kinases.

Cell - 28 Dec 2007

Takai Hiroyuki, Wang Richard C, Takai Kaori K, Yang Haijuan, de Lange Titia

Abstract excerpt

We report an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, we found no obvious telomeric function for mammalian Tel2. Targeted gene deletion showed that mouse Tel2 is essential in embryonic development, embryonic stem (ES) cells, and...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Source

Identifiers

PMID: 18160036
DOI: 10.1016/j.cell.2007.10.052

Genes

ATM
ATR
SMG1
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tel2 regulates the stability of PI3K-related protein kinases.PMID 18160036Read ↗

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