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Article

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.

The Journal of biological chemistry - 9 Apr 2004

Reinke Aaron, Anderson Scott, McCaffery J Michael, Yates John, Aronova Sofia, Chu Stephanie, Fairclough Stephen, Iverson Cory, Wedaman Karen P, Powers Ted

Abstract excerpt

The Tor1p and Tor2p kinases, targets of the therapeutically important antibiotic rapamycin, function as components of two distinct protein complexes in yeast, termed TOR complex 1 (TORC1) and TORC2. TORC1 is responsible for a wide range of rapamycin-sensitive cellular activities and contains, in addition to Tor1p or Tor2p, two highly conserved proteins, Lst8p and Kog1p. By identifying proteins that co-purify with...

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PMID: 14736892
DOI: 10.1074/jbc.M313062200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.PMID 14736892Read ↗

Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling.Semantic proximity Read ↗

Structure-based engineering of Tor complexes uncovers different roles of two types of yeast TORC1sSemantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes.Semantic proximity Read ↗

Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.Semantic proximity Read ↗

Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway.Semantic proximity Read ↗

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiaeSemantic proximity Read ↗

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

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