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Article

Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.

Genetics - 1 Jul 2012

Genereaux Julie, Kvas Stephanie, Dobransky Dominik, Karagiannis Jim, Gloor Gregory B, Brandl Christopher J

Abstract excerpt

Tra1 is a 3744-residue component of the Saccharomyces cerevisiae SAGA, NuA4, and ASTRA complexes. Tra1 contains essential C-terminal PI3K and FATC domains, but unlike other PIKK (phosphoinositide three-kinase-related kinase) family members, lacks kinase activity. To analyze functions of the FATC domain, we selected for suppressors of tra1-F3744A, an allele that results in slow growth under numerous conditions of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22505622
DOI: 10.1534/genetics.112.140459
PMCID: PMC3389973

Genes

TTI2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.PMID 22505622Read ↗

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A tti1 mutation in the Tel2-Tti1-Tti2 complex specifically eliminates the cellular function of Rad3ATR, but not that of other PIKKs in fission yeast.Semantic proximity Read ↗

The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.Semantic proximity Read ↗

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The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.Semantic proximity Read ↗

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