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Article

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.

Molecular biology of the cell - 1 Aug 1999

Alarcon C M, Heitman J, Cardenas M E

Abstract excerpt

In complex with FKBP12, the immunosuppressant rapamycin binds to and inhibits the yeast TOR1 and TOR2 proteins and the mammalian homologue mTOR/FRAP/RAFT1. The TOR proteins promote cell cycle progression in yeast and human cells by regulating translation and polarization of the actin cytoskeleton. A C-terminal domain of the TOR proteins shares identity with protein and lipid kinases, but only one substrate...

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Identifiers

PMID: 10436010
DOI: 10.1091/mbc.10.8.2531
PMCID: PMC25485

Genes

ATM
ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.PMID 10436010Read ↗

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