Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of connexin43 and connexin45 does not disturb pre- and peri-implantation development.

Zygote (Cambridge, England) - 1 Jun 2016

Nishii Kiyomasa, Kobayashi Yasushi, Shibata Yosaburo

Abstract excerpt

Gap junctional intercellular communication is assumed to play an important role during pre- and peri-implantation development. In this study, we eliminated connexin43 (Cx43) and connexin45 (Cx45), major gap junctional proteins in the pre- and peri-implantation embryo. We generated Cx43 -/- Cx45 -/- embryos by Cx43 +/- Cx45 +/- intercrossing, because mice deficient in Cx43 (Cx43 -/-) exhibit perinatal lethality...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Connexin 43
Share to Connexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo Culture Techniques

Share to Embryo Implantation

Share to Embryo, Mammalian

Share to Immunohistochemistry

Share to Mice, Knockout

Source

Identifiers

PMID: 27172058
DOI: 10.1017/S0967199415000386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of connexin43 and connexin45 does not disturb pre- and peri-implantation development.PMID 27172058Read ↗

Normal development of preimplantation mouse embryos deficient in gap junctional coupling.Semantic proximity Read ↗

Gap junctions and the connexin protein family.Semantic proximity Read ↗

Unique and shared functions of different connexins in mice.Semantic proximity Read ↗

Downregulation of Connexin 45 Gene Products During Mouse Heart DevelopmentSemantic proximity Read ↗

Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion.Semantic proximity Read ↗

Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development.Semantic proximity Read ↗

Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice.Semantic proximity Read ↗

Failure of spermatogenesis in mice lacking connexin43.Semantic proximity Read ↗

C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice.Semantic proximity Read ↗

Rescue of oogenesis in Cx37-null mutant mice by oocyte-specific replacement with Cx43.Semantic proximity Read ↗

Defects in the germ line and gonads of mice lacking connexin43.Semantic proximity Read ↗

Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.