Article
Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice.
Circulation research - 1 Sept 2000
Kirchhoff S, Kim J S, Hagendorff A, Thönnissen E, Krüger O, Lamers W H, Willecke K
Abstract excerpt
Connexin40-deficient (Cx40(-/-)/Cx43(+/+)) and connexin43-heterozygous knockout mice (Cx40(+/+)/Cx43(+/-)) are viable but show cardiac conduction abnormalities. The ECGs of adult double heterozygous animals (Cx40(+/-)/Cx43(+/-)) suggest additive effects of Cx40 and Cx43 haploinsufficiency on ventricular, but not on atrial, conduction. We also observed additive effects of both connexins on cardiac morphogenesis....
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