Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Failure of spermatogenesis in mice lacking connexin43.

Biology of reproduction - 1 Sept 2001

Roscoe W A, Barr K J, Mhawi A A, Pomerantz D K, Kidder G M

Abstract excerpt

Connexin43 (Cx43), a gap junction protein encoded by the Gja1 gene, is expressed in several cell types of the testis. Cx43 gap junctions couple Sertoli cells with each other, Leydig cells with each other, and spermatogonia/spermatocytes with Sertoli cells. To investigate the role of this communication pathway in spermatogenesis, we studied postnatal testis development in mice lacking Cx43. Because such mice die...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Spermatogenesis
Share to Seminiferous Tubules
Share to Connexin 43

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Leydig Cells

Share to Luteinizing Hormone

Share to Oligospermia

Share to Proliferating Cell Nuclear Antigen

Source

Identifiers

PMID: 11514348
DOI: 10.1095/biolreprod65.3.829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure of spermatogenesis in mice lacking connexin43.PMID 11514348Read ↗

Defects in the germ line and gonads of mice lacking connexin43.Semantic proximity Read ↗

Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal miceSemantic proximity Read ↗

Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice.Semantic proximity Read ↗

Blood–testis barrier and Sertoli cell function: lessons from SCCx43KO miceSemantic proximity Read ↗

Transplantation of wild-type spermatogonia leads to complete spermatogenesis in testes of cyclic 3',5'-adenosine monophosphate response element modulator-deficient mice.Semantic proximity Read ↗

Absence of connexin43 and connexin45 does not disturb pre- and peri-implantation development.Semantic proximity Read ↗

Characterization of Spermatogonial Stem Cell Maturation and Differentiation in Neonatal Mice1Semantic proximity Read ↗

Sertoli cell ablation and replacement of the spermatogonial niche in mouseSemantic proximity Read ↗

Ultrastructural observations of spermatogenesis in mice resulting from transplantation of mouse spermatogonia.Semantic proximity Read ↗

Sertoli cell replacement in explanted mouse testis tissue supporting host spermatogenesis†Semantic proximity Read ↗

Disrupted traffic of connexin 43 in human testicular seminoma cells: overexpression of Cx43 induces membrane location and cell proliferation decreaseSemantic proximity Read ↗

Development of Germ Cell Transplants in Mice1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.