Article
Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2005
Kibschull Mark, Magin Thomas M, Traub Otto, Winterhager Elke
Abstract excerpt
The overlapping expression of gap junctional connexins in tissues has indicated that the channels may compensate for each other. During development, Cx31 and Cx43 are coexpressed in preimplantation embryos, in the spongiotrophoblast of the placenta and in the epidermis. This study shows that Cx31/Cx43 double-deficient mice exhibit the known phenotypes of the single-knockout strains but no combined effects. Thus,...
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