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Article

Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion.

Journal of molecular and cellular cardiology - 1 Jan 2004

Eckardt D, Theis M, Degen J, Ott T, van Rijen H V M, Kirchhoff S, Kim J-S, de Bakker J M T, Willecke K

Abstract excerpt

The gap junction protein Connexin43 (Cx43) is expressed in various cell types during embryonic development and in adult mice. Cx43 null mice (Cx43-/-) die perinatally due to cardiac malformation. In order to define the major functional role of Cx43 gap junction channels in adult mice and to circumvent perinatal death as well as direct or indirect compensation of Cx43 deficiency during development, we established...

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Identifiers

PMID: 14734052
DOI: 10.1016/j.yjmcc.2003.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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