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Article

Downregulation of Connexin 45 Gene Products During Mouse Heart Development

25 Jun 1999

Abstract excerpt

The electrical activity in heart is generated in the sinoatrial node and then propagates to the atrial and ventricular tissues. The gap junction channels that couple the myocytes are responsible for this propagation process. The gap junction channels are dodecamers of transmembrane proteins of the connexin (Cx) family. Three members of this family have been demonstrated to be synthesized in the cardiomyocytes:...

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Identifiers

PMID: 10381888
DOI: 10.1161/01.res.84.12.1365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Downregulation of Connexin 45 Gene Products During Mouse Heart DevelopmentPMID 10381888Read ↗

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C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice.Semantic proximity Read ↗

Remodelling of gap junctions and connexin expression in diseased myocardium.Semantic proximity Read ↗

Modulation of cardiac gap junction expression and arrhythmic susceptibility.Semantic proximity Read ↗

Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes.Semantic proximity Read ↗

Gap junction remodeling and cardiac arrhythmogenesis: cause or coincidence?Semantic proximity Read ↗

Connexin43 Expression Levels Influence Intercellular Coupling and Cell Proliferation of Native Murine Cardiac FibroblastsSemantic proximity Read ↗

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